Constrained optimization in simulation: a novel approach.

This paper presents a novel heuristic for constrained optimization of random computer simulation models, in which one of the simulation outputs is selected as the objective to be minimized while the other outputs need to satisfy prespeci¯ed target values. Besides the simulation outputs, the simulation inputs must meet prespeci¯ed constraints including the constraint that the inputs be integer. The proposed heuristic combines (i) experimental design to specify the simulation input combinations, (ii) Kriging (also called spatial correlation modeling) to analyze the global simulation input/output data that result from this experimental design, and (iii) integer nonlinear programming to estimate the optimal solution from the Kriging metamodels. The heuristic is applied to an (s, S) inventory system and a realistic call-center simulation model, and compared with the popular commercial heuristic OptQuest embedded in the ARENA versions 11 and 12. These two applications show that the novel heuristic outperforms OptQuest in terms of search speed (it moves faster towards high-quality solutions) and consistency of the solution quality.

Kriging metamodeling in constrained simulation optimization: an explorative study.

Simulation; Optimization; Studies;

Investigation of Smart Responses of Human Serum Albumin in Fever Condition: An In Vitro Approach

To move real objects, our hand needs to get in direct physical contact with the object. However, this is not necessarily the case when interacting with virtual objects, for example when displacing objects on tablets by swipe movements. Here, we performed two experiments to study the behavioral strategies of these movements, examining how visual information about the virtual object is mapped into a swipe that moves the object into a goal location. In the first experiment, we investigated how swiping behavior depends on whether objects were located within or outside the swiping workspace. Results show that participants do not start the swipe movement by placing their finger on the virtual object, as they do when reaching to real objects, but rather keep a systematic distance between the object location and the initial swipe location. This mismatch, which was experimentally imposed by placing the object outside the workspace, also occurred when the object was within the workspace. In the second experiment, we investigated which factors determine this mismatch by systematically manipulating the initial hand location, the location of the object and the location of the goal. Dimensionality reduction of the data showed that three factors are taken into account when participants choose the initial swipe location: the expected total movement distance, the distance between their finger on the screen and the object, and a preference not to cover the object. The weight given to each factor differed among individuals. These results delineate, for the first time, the flexibility of visuomotor associations in the virtual world

Is locally advanced head and neck cancer ‘increasing’ in the Netherlands? The paradox of absolute numbers, standardized incidence rates and proportional share

Background: Several reports have indicated that locally advanced head and neck cancer (LAHNC) has increased in the past decade. However, incidence trends cannot be easily compared because slightly different definitions of LAHNC were used. Aim: To investigate if the incidence of locally advanced disease (LAD) in the oral cavity, oropharynx, hypopharynx and larynx is indeed increasing over time, considering the growing and ageing population in the Netherlands. Patients and methods: Data were obtained from the Netherlands Cancer Registry (NCR). Primary head and neck squamous cell carcinomas of the oral cavity, oropharynx, hypopharynx and larynx diagnosed between 1989 and 2017 were included. Yearly numbers and European standardized incidence rates (ESRs) were reported by extent of disease. The annual percentage change (APC) over time in ESRs was calculated to assess trends. Results: Absolute numbers and ESRs of LAD increased over time for oral cavity and most prominently for oropharynx carcinomas (before 1996, APC: 0.4, 95%CI: 0.1; 0.8 and APC: 5.7 (95%CI: 3.1; 8.4) after 1996: 1.5 (1.0; 2.0) respectively. For hypopharynx cancer the absolute number and ESR of LAD increased until 1997 and declined with 0.8% per year since 1997. Absolute numbers of patients with larynx cancer stayed stable over time, while ESR decreased (APC: −0.8 (95%CI: −1.1; −0.6)). Conclusion: The perception of an increasing trend in LAD in the Netherlands can be attributed to the increasing incidence of oral cavity and oropharynx carcinomas. For LAD of the hypopharynx a decreasing trend was observed. In larynx cancer, the proportional share of LAD of the larynx increased, even though incidence rates declined.</p

Searching for unknown open clusters in the Tycho-2 catalog

We present 11 new open cluster candidates found in a systematic search for unknown star clusters using the astrometric and photometric data included in the Tycho2 catalog. The possible existence of these stellar aggregates is supported by the analysis of proper motions, color-magnitude diagrams, stellar density distributions, and by the visual inspection of the Digitized Sky Survey (DSS) plates. With these tools we were able to determine mean absolute proper motions as well as preliminary reddenings, distances and ages for the majority of the candidates. We found that most of them are possibly nearby (closer than about 600 pc) open clusters never studied before.Comment: 14 pages, 6 figures. Accepted by A&

The complex structure of Abell 2345: a galaxy cluster with non-symmetric radio relics

We aim to obtain new insights into the internal dynamics of the cluster Abell 2345. This cluster exhibits two non-symmetric radio relics well studied through recent, deep radio data. Our analysis is based on redshift data for 125 galaxies acquired at the Telescopio Nazionale Galileo and on new photometric data acquired at the Isaac Newton Telescope. We also use ROSAT/HRI archival X-ray data. We combine galaxy velocities and positions to select 98 cluster galaxies and analyze the internal dynamics of the cluster. We estimate a mean redshift =0.1789 and a LOS velocity dispersion \sigma ~ 1070 km/s. The two-dimensional galaxy distribution reveals the presence of three significant peaks within a region of ~ 1 Mpc (the E, NW, and SW peaks). The spectroscopic catalog confirms the presence of these three clumps. The total mass of the cluster is very uncertain: M~ 2 10^15 solar masses. The E clump well coincides with the main mass peak as recovered from the weak gravitational lensing analysis and is off-set to the east from the BCG by ~ 1.3 arcmin. The ROSAT X-ray data also show a very complex structure, mainly elongated in the E-W direction, with two (likely three) peaks in the surface brightness distribution, which, however, are off-set from the position of the peaks in the galaxy density. The observed phenomenology agrees with the hypothesis that we are looking at a complex cluster merger occurring along two directions: a major merger along the ~ E-W direction (having a component along the LOS) and a minor merger in the western cluster regions along the ~ N-S direction, roughly parallel to the plane of the sky.Comment: 27 pages, 11 figures and 3 tables. Accepted for publication on Astronomy and Astrophysic

Дослідження підходів до оцінки стану конкурентоспроможності підприємств

Мета статті – наведення підходів до оцінки стану конкурентоспроможності підприємств

The Origin of the Bifurcation in the Sagittarius Stream

The latest Sloan Digital Sky Survey data reveal a prominent bifurcation in the distribution of debris of the Sagittarius dwarf spheroidal (Sgr) beginning at a right ascension of roughly 190 degrees. Two branches of the stream (A and B) persist at roughly the same heliocentric distance over at least 50 degrees of arc. There is also evidence for a more distant structure (C) well behind the A branch. This paper provides the first explanation for the bifurcation. It is caused by the projection of the young leading (A) and old trailing (B) tidal arms of the Sgr, whilst the old leading arm (C) lies well behind A. This explanation is only possible if the halo is close to spherical, as the angular difference between the branches is a measure of the precession of the orbital plane.Comment: ApJ, in pres